Connected via causeway to U.S. Highway 1 at mile marker 70, near the upper end of Long Key (I).

Jewfish Kay on Blunt chart (1846). Jewfish Key on Charles Smith's 1873 survey map.

For a period in the 1950's & 1960's, the key was owned by the Greyhound Bus Company. During that period it was named Greyhound Key. The first bus connection to Miami was in 1928, from nearby Craig Key.